High-Protein Spinach and Artichoke Chicken Casserole

This High-Protein Spinach and Artichoke Chicken Casserole transforms the creamy, indulgent flavors of the classic dip into a full meal. Each serving delivers 47 grams of protein, making it perfect for keeping you full and energized. The trick? Lean chicken breast and blended cottage cheese, which boost protein without compromising that creamy, cheesy goodness.

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Months ago, I set out to create a healthier version of spinach and artichoke dip turned into a casserole. After success with my high-protein Jalapeño Popper Chicken Casserole and Creamy Buffalo Chicken Casserole, I knew a spinach-artichoke twist was next. Everyone loves that classic dip—why not make it a nourishing dinner?

At first, my first attempt was a total disaster. I mean, truly inedible. It was so disappointing that I couldn’t even taste it. But after regrouping and testing a few tweaks, I finally perfected this recipe. And now? It’s creamy, flavorful, and absolutely packed with protein.

Why You’ll Love This High-Protein Spinach and Artichoke Chicken Casserole

• 47 grams of protein per serving – ideal for staying satisfied.
• Dip turned dinner – your favorite appetizer is now a full meal.
• Gluten-free and low-carb – perfect for healthy eating.
• Minimal prep, maximum flavor – simple, approachable steps.
• Cottage cheese magic – adds protein while keeping it creamy, and you won’t even notice it’s there.

What You’ll Need to Make This Casserole

• Cottage Cheese: Traditional spinach-artichoke dips rely on cream cheese, mayo, and sour cream. By blending cottage cheese instead, you get a protein boost without losing creaminess. I recommend 4% fat, but 2% works too.
• Garlic: Fresh cloves blended into the cottage cheese for aromatic flavor.
• Simple Seasonings: Kosher salt, black pepper, and onion powder for balanced flavor.
• Avocado Oil: For cooking chicken—its high smoke point is perfect, though olive oil works fine too.
• Boneless Skinless Chicken Breast: Adds lean protein and makes this casserole a filling meal.
• Frozen Chopped Spinach: Thaw and squeeze out excess liquid to avoid a watery casserole. Fresh spinach can be used if prepped carefully.
• Canned Artichoke Hearts: Drain well and chop finely. Fresh artichokes are an option if you’re adventurous.
• Shredded Mozzarella: Low-moisture, part-skim cheese keeps the casserole from getting too watery.
• Grated Parmesan: Freshly grated for optimal melt and flavor.

How To Make This High-Protein Spinach and Artichoke Chicken Casserole

Dry Brine the Chicken

Preheat the oven to 350°F. For extra juicy chicken, season cubed chicken breast with kosher salt and let it sit at room temperature for at least 20 minutes. This optional step works like a “dry brine,” locking in moisture and flavor.

Squeeze Out Liquid from Spinach and Artichokes

Place drained artichoke hearts in a clean dish towel or cheesecloth and squeeze out excess liquid. Chop finely.
Use the same towel for thawed spinach—removing all liquid is crucial for a creamy yet firm casserole.

Sauté Chicken

Heat a large pan over medium heat. Add avocado oil and then the chicken in a single layer. Season with black pepper. Cook for 2–3 minutes per side until almost cooked through. Remove from pan and set aside.

Blend Cottage Cheese

In a small food processor, blend cottage cheese, garlic, salt, black pepper, and onion powder until smooth. This creates the creamy base of your casserole while keeping it high in protein.

Assemble the Casserole

In a baking dish, combine cooked chicken, spinach, artichokes, blended cottage cheese, and two-thirds of the mozzarella and Parmesan cheese (reserve the rest for topping). Spread evenly.

Bake and Add Cheese

Cover with foil and bake for 20 minutes. Remove foil, sprinkle remaining cheese on top, and bake uncovered for another 10 minutes. For a golden, bubbly finish, broil for a few minutes at the end.

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Can I Use Fresh Spinach or Artichokes?

Frozen spinach and canned artichokes are convenient and consistent in texture. If using fresh spinach, remove tough stems, chop, and wilt in a pan before squeezing out excess liquid. Fresh artichokes require more prep, so experiment carefully.

Is This a Full Meal?

Absolutely! With chicken and cottage cheese, this casserole is a filling lunch or dinner. One serving packs 47 grams of protein, making it a satisfying, nutritious choice.

Can I Prep Ahead?

Yes. After combining all ingredients in the baking dish, cover and refrigerate until ready to bake. Follow the baking instructions as usual for a fresh, hot meal.

Storing Leftovers

Allow leftovers to cool completely. Transfer to an airtight container and refrigerate for several days. Reheat before serving for melty, cheesy perfection.

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